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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRKDC
All Species:
21.52
Human Site:
Y2288
Identified Species:
52.59
UniProt:
P78527
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P78527
NP_001075109.1
4128
469089
Y2288
M
A
N
D
L
P
P
Y
D
P
Q
C
G
I
Q
Chimpanzee
Pan troglodytes
XP_001147162
4128
468882
Y2288
M
A
N
D
L
P
P
Y
D
P
Q
C
G
I
Q
Rhesus Macaque
Macaca mulatta
XP_001100610
4128
469402
Y2288
M
A
N
D
L
P
P
Y
D
P
Q
C
G
I
Q
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P97313
4128
471369
Y2284
I
A
N
N
L
P
P
Y
D
P
N
C
D
I
T
Rat
Rattus norvegicus
NP_001101797
2098
241314
D422
M
L
L
Q
L
M
T
D
I
L
C
R
E
Q
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514950
4153
474137
Y2310
L
A
N
N
L
P
P
Y
D
P
K
C
G
I
D
Chicken
Gallus gallus
Q8QGX4
4134
472639
F2287
L
A
N
N
L
P
P
F
D
L
K
C
E
I
D
Frog
Xenopus laevis
Q9DEI1
4146
473487
L2308
L
A
N
N
F
S
P
L
D
P
K
C
G
I
D
Zebra Danio
Brachydanio rerio
XP_001919588
4119
467204
Y2294
M
A
N
N
L
P
P
Y
D
A
A
C
G
I
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781813
1817
205237
S141
K
L
L
F
M
L
P
S
I
H
G
Q
P
K
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
97.5
N.A.
N.A.
79.1
39.2
N.A.
74.1
68.8
64
58.5
N.A.
N.A.
N.A.
N.A.
20.8
Protein Similarity:
100
99.8
98.8
N.A.
N.A.
88.7
44.7
N.A.
85.4
82.5
79.8
76.1
N.A.
N.A.
N.A.
N.A.
31.6
P-Site Identity:
100
100
100
N.A.
N.A.
66.6
20
N.A.
73.3
53.3
53.3
73.3
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
N.A.
N.A.
80
20
N.A.
93.3
80
73.3
86.6
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
80
0
0
0
0
0
0
0
10
10
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
10
80
0
0
0
% C
% Asp:
0
0
0
30
0
0
0
10
80
0
0
0
10
0
30
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
20
0
10
% E
% Phe:
0
0
0
10
10
0
0
10
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
10
0
60
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% H
% Ile:
10
0
0
0
0
0
0
0
20
0
0
0
0
80
0
% I
% Lys:
10
0
0
0
0
0
0
0
0
0
30
0
0
10
0
% K
% Leu:
30
20
20
0
80
10
0
10
0
20
0
0
0
0
0
% L
% Met:
50
0
0
0
10
10
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
80
50
0
0
0
0
0
0
10
0
0
0
0
% N
% Pro:
0
0
0
0
0
70
90
0
0
60
0
0
10
0
0
% P
% Gln:
0
0
0
10
0
0
0
0
0
0
30
10
0
10
40
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% R
% Ser:
0
0
0
0
0
10
0
10
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
20
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
60
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _